Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
| PAG Title | Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD |
| PAG ID | PEX002210 |
| Type | A |
| Source Link |  Pfam |
| Publication Reference | NA |
| PAG Description | The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function 1. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 0 |
| Information Content | Poor |
| Other IDs | PF00160 |
| Base PAG ID | PEX002210 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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